Microglia are the brain resident innate immune cells that play critical roles in brain aging, neuroinflammation and neurodegenerative diseases. Immune activation of microglia can play protective and/or detrimental roles in a context-specific manner. We study the cellular and molecular mechanisms that regulate microglial responses to amyloid-beta pathology. We utilize high-resolution confocal microscopy imaging, transcriptomics analysis, immune and biochemical assays, and animal behavior studies to address these questions. We aim to identify divergent roles of genes that govern myeloid cell homeostasis in the brain and periphery.

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Collaborators: Prof. T. Govindaraju, JNCASR